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Nobel Prize 2018: Major highlights and motivations

Nobel-prize-2018

Time and again, people have proved that strong strings withstand the tests, no matter how great the pressure! Nobel Prizes were thus, introduced keeping in mind the strength that inspires billions.

Imagine sleeping on a footpath or park bench, or studying under street lights, or serving as slaves to ruthless people, or working so hard that you almost died. Imagine protecting others with your life in the line, imagine being shot if you raised your voice to protest.

IMAGINE.

People receive awards not just by doing something great, but by finding greatness in hardships, in challenges they face to achieve their goals. Such people are idols, for they show how to achieve greatness, which is far worthy than success.

Here are the Nobel Prize winners of 2018 whose outstanding works made the world gasp in wonder.

 

Nobel Prize for Medicine or Physiology

Nobel-Prize-for-Medicine-or-Physiology

James P. Allison and TasukuHonjo will receive the 2018 Nobel Prize in Physiology or Medicine for their discovery of cancer therapy by inhibition of negative immune regulation. Allison’s early research focused on understanding how the human immune system defends the body from pathogens and cancers, with an emphasis on the role of immune cells called T cells. He went on to develop an antibody that blocks a CTLA-4 protein that led to the disintegration of existing tumors. Ipilimumab(antibody) was the first remedial which improved survival for patients with this deadly disease.

Honjo researched & identified the protein PD-1 on immune cells. After meticulous research, he saw that it also operates as a brake on T cells, but that it functions in a different way to CTLA-4.

 

Nobel Prize for Chemistry

Nobel-Prize-for-Chemistry

The 2018 Nobel Prize in Chemistry has been bestowed on Frances H. Arnold for the “directed evolution of enzymes” and, to George P. Smith and Gregory P. Winter for the “phage display of peptides and antibodies.”

In simple words, Directed Evolution is a lab method where mutation and screening in used to speed up the genes natural selection process. Arnold introduced random mutations into the gene for a starting enzyme, used microbial genes and screened mutated genes for the desired activity.

Smith’s research was sequencing the chromosomes of the collected phages to produce genes for proteins with desired binding affinity. Winter extended phage display to screening for different antibodies.

Their work involves techniques that are now, used worldwide and their research will set new patterns for upcoming researchers.

 

Nobel Prize for Peace

Nobel-Prize-for-Peace

Gynecologist Denis Mukwege and Yazidi campaigner Nadia Murad have jointly received the Nobel Prize for peace.

Nadia’s story is sad and inspiring at the same time. She was abused and raped by the IS army. Verbal and violent abuses are a part of the IS military strategy and, girls like Nadia served as weaponry against religious minorities.

Dr. Mukwege has spent his time in helping the victims of sexual violence in the Democratic Republic of Congo. He and his staff have treated thousands of victims to such assaults.

They have received a high appraisal for their efforts to prohibit sexual violence in war and armed conflicts.

 

There are so many big and small things that our eyes miss, but once seen through, they show what human beings are capable of achieving. Don’t be afraid to face challenges. Just so you know, “if you to be in history, you have to solve the mystery!”

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